Hur programmerare arbetar
نویسندگان
چکیده
Recension av: Espen Suenson 2015. How Computer Programmers Work – Understanding Software Development in Practice. Turku: Department of Information Technologies, Åbo Akademi. 287 pp. ISBN: 978-952-12-3225-1 ISSN: 1239-1883.
منابع مشابه
Kul Hur
By using the notion of fuzzy functions introduced by Dib and Youssef, we obtain fuzzy analogues of some results concerning ordinary functions. In particular, we give the definition different from one of invertible fuzzy function introduced by Dib and Youssef. And we show that the two definitions are equivalent. Furthermore, we introduce the concepts of fuzzy increasing functions and fuzzy isomo...
متن کاملHuR function in disease.
The cytoplasmic events that control mammalian gene expression, primarily mRNA stability and translation, potently influence the cellular response to internal and external signals. The ubiquitous RNA-binding protein (RBP) HuR is one of the best-studied regulators of cytoplasmic mRNA fate. Through its post-transcriptional influence on specific target mRNAs, HuR can alter the cellular response to ...
متن کاملReduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence
The RNA-binding protein, HuR, associates with the HuR mRNA, but the consequences of this interaction are unknown. Here, we use human diploid fibroblasts (HDFs) and cervical carcinoma cells to study this regulatory paradigm. Ectopic overexpression of HuR potently enhanced the translation and cytoplasmic levels of endogenous HuR, but did not affect HuR mRNA levels. Inhibition of CRM1 function by ...
متن کاملTyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs
In response to stress conditions, many mammalian mRNAs accumulate in stress granules (SGs) together with numerous RNA-binding proteins that control mRNA turnover and translation. However, the signaling cascades that modulate the presence of ribonucleoprotein (RNP) complexes in SGs are poorly understood. Here, we investigated the localization of human antigen R (HuR), an mRNA-stabilizing RNA-bin...
متن کاملThe fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. Thus, small molecules that interfere with the HuR-ARE interaction could potentially inhibit cancer cell growth and progression. Using a fluorescence polarization (FP) co...
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ژورنال
عنوان ژورنال: Budkavlen
سال: 2023
ISSN: ['0302-2447', '2736-8246']
DOI: https://doi.org/10.37447/bk.129608